InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF5A

Summary

InnateDB Protein

IDBP-24320.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF5A

Protein Name

eukaryotic translation initiation factor 5A

Synonyms

EIF-5A; EIF5A1; eIF5AI;

Species

Homo sapiens

Ensembl Protein

ENSP00000336776

InnateDB Gene

IDBG-24314 (EIF5A)

Protein Structure

UniProt Annotation

Function

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. {ECO:0000269PubMed:15371445, ECO:0000269PubMed:15452064, ECO:0000269PubMed:16987817, ECO:0000269PubMed:17187778, ECO:0000269PubMed:17360499}.

Subcellular Localization

Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.

Disease Associations

Tissue Specificity

Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level). {ECO:0000269PubMed:16519677}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003746	translation elongation factor activity
GO:0005515	protein binding
GO:0017070	U6 snRNA binding
GO:0043022	ribosome binding
GO:0044822	poly(A) RNA binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006406	mRNA export from nucleus
GO:0006452	translational frameshifting
GO:0006611	protein export from nucleus
GO:0006913	nucleocytoplasmic transport
GO:0006915	apoptotic process
GO:0008284	positive regulation of cell proliferation
GO:0008612	peptidyl-lysine modification to peptidyl-hypusine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045901	positive regulation of translational elongation
GO:0045905	positive regulation of translational termination

Cellular Component

GO:0005634	nucleus
GO:0005642	annulate lamellae
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001884 Translation elongation factor IF5A
IPR005824 KOW
IPR008991 Translation protein SH3-like domain
IPR012340 Nucleic acid-binding, OB-fold
IPR020189 Translation elongation factor, IF5A C-terminal

PFAM

PF00467
PF01287

PRINTS

PIRSF

PIRSF003025

SMART

SM00739

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt