InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KEAP1

Summary

InnateDB Protein

IDBP-243247.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KEAP1

Protein Name

kelch-like ECH-associated protein 1

Synonyms

INrf2; KLHL19;

Species

Homo sapiens

Ensembl Protein

ENSP00000377245

InnateDB Gene

IDBG-27562 (KEAP1)

Protein Structure

UniProt Annotation

Function

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. {ECO:0000269PubMed:14585973, ECO:0000269PubMed:15379550, ECO:0000269PubMed:15572695, ECO:0000269PubMed:15983046, ECO:0000269PubMed:17046835}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.

Disease Associations

Tissue Specificity

Broadly expressed, with highest levels in skeletal muscle. {ECO:0000269PubMed:15379550}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 115 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	115 [view]
Protein-Protein	112 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0010499	proteasomal ubiquitin-independent protein catabolic process
GO:0016567	protein ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0030496	midbody
GO:0031463	Cul3-RING ubiquitin ligase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

PIRSF037037

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt