Version 5.4
Homo sapiens Protein: NLN
Summary
InnateDB Protein IDBP-24330.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NLN
Protein Name neurolysin (metallopeptidase M3 family)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000370372
InnateDB Gene IDBG-24328 (NLN)
Protein Structure
UniProt Annotation
Function Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. {ECO:0000250}.
Subcellular Localization Mitochondrion intermembrane space {ECO:0000250}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0042277 peptide binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001567 Peptidase M3A/M3B
PFAM PF01432
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BYT8
PhosphoSite PhosphoSite-Q9BYT8
TrEMBL Q8NDD9
UniProt Splice Variant
Entrez Gene 57486
UniGene Hs.611336
RefSeq NP_065777
HUGO HGNC:16058
OMIM 611530
CCDS CCDS3989
HPRD 07495
IMGT
EMBL AB033052 AC008958 AC016643 AJ300837 AL834241
GenPept BAA86540 CAC27329 CAD38918

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca