InnateDB Protein
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IDBP-24337.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FGFR1OP2
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Protein Name
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FGFR1 oncogene partner 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000323763
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InnateDB Gene
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IDBG-24333 (FGFR1OP2)
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Protein Structure
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Function |
May be involved in wound healing pathway. {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
Note=A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.
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Tissue Specificity |
Expressed in bone marrow, spleen and thymus.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
42
[view]
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Protein-Protein |
42
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008555
Suppressor of IKBKE 1
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PFAM |
PF05769
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NVK5
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PhosphoSite |
PhosphoSite-Q9NVK5
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TrEMBL |
F5GX47
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UniProt Splice Variant |
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Entrez Gene |
26127
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UniGene |
Hs.602646
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RefSeq |
NP_001165358
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HUGO |
HGNC:23098
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OMIM |
608858
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CCDS |
CCDS53767
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HPRD |
10589
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IMGT |
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EMBL |
AC024093
AC024896
AF161472
AK001534
AL117608
AY506561
BC032143
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GenPept |
AAF29087
AAH32143
AAR91611
BAA91745
CAB56012
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