Version 5.4
Homo sapiens Protein: SLC12A8
Summary
InnateDB Protein IDBP-243532.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC12A8
Protein Name solute carrier family 12 (potassium/chloride transporters), member 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000377112
InnateDB Gene IDBG-281667 (SLC12A8)
Protein Structure
UniProt Annotation
Function Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. {ECO:0000269PubMed:11863360}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations Note=SLC12A8 has been identified as a possible susceptibility gene for psoriasis mapped to chromosome 3q21 (PSORS5).
Tissue Specificity Ubiquitous with very low level in normal skin. {ECO:0000269PubMed:11863360}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0015293 symporter activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0006810 transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004841 Amino acid permease/ SLC12A domain
IPR011527 ABC transporter type 1, transmembrane domain
PFAM PF00324
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A0AV02
PhosphoSite PhosphoSite-A0AV02
TrEMBL C9IZN2
UniProt Splice Variant
Entrez Gene 84561
UniGene Hs.658514
RefSeq NP_001182412
HUGO HGNC:15595
OMIM 611316
CCDS CCDS43143
HPRD 11563
IMGT
EMBL AC055752 AC108688 AC117488 AF345197 AF389851 AF390442 AK026841 BC020506 BC063528 BC126158 BC126160 BX538023 CR457363 CR749632
GenPept AAH20506 AAH63528 AAI26159 AAI26161 AAK94307 AAM73657 AAO49174 BAB15571 CAD97969 CAG33644 CAH18426

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca