InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHRNA10

Summary

InnateDB Protein

IDBP-24369.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHRNA10

Protein Name

cholinergic receptor, nicotinic, alpha 10

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000250699

InnateDB Gene

IDBG-24367 (CHRNA10)

Protein Structure

UniProt Annotation

Function

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. {ECO:0000269PubMed:11752216}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes. {ECO:0000269PubMed:11752216, ECO:0000269PubMed:15531379}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005102	receptor binding
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005262	calcium channel activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007271	synaptic transmission, cholinergic
GO:0042127	regulation of cell proliferation
GO:0042472	inner ear morphogenesis
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005892	acetylcholine-gated channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0043204	perikaryon
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002394 Nicotinic acetylcholine receptor
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding

PFAM

PF02932
PF02931

PRINTS

PR00254
PR00252

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9GZZ6