Version 5.4
Homo sapiens Protein: IGLL1
Summary
InnateDB Protein IDBP-2437.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGLL1
Protein Name immunoglobulin lambda-like polypeptide 1
Synonyms 14.1; AGM2; CD179b; IGL1; IGL5; IGLJ14.1; IGLL; IGO; IGVPB; VPREB2;
Species Homo sapiens
Ensembl Protein ENSP00000249053
InnateDB Gene IDBG-2433 (IGLL1)
Protein Structure
UniProt Annotation
Function Critical for B-cell development. {ECO:0000269PubMed:9419212}.
Subcellular Localization Secreted {ECO:0000269PubMed:9419212}.
Disease Associations Agammaglobulinemia 2, autosomal recessive (AGM2) [MIM:613500]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269PubMed:9419212}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed only in pre-B-cells and a special B- cell line (which is surface Ig negative). {ECO:0000269PubMed:2128466}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006955 immune response
Cellular Component
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P15814
PhosphoSite PhosphoSite-P15814
TrEMBL
UniProt Splice Variant
Entrez Gene 3543
UniGene Hs.348935
RefSeq NP_690594
HUGO HGNC:5870
OMIM 146770
CCDS CCDS13810
HPRD 00905
IMGT
EMBL AP000345 BC012293 BC030239 M27749 M34511 M34512 M34513 X03528 X03530
GenPept AAA36096 AAA36100 AAH12293 AAH30239 CAA27229 CAA27231

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca