InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPRZ1

Summary

InnateDB Protein

IDBP-243710.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRZ1

Protein Name

protein tyrosine phosphatase, receptor-type, Z polypeptide 1

Synonyms

HPTPZ; HPTPzeta; phosphacan; PTP-ZETA; PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta;

Species

Homo sapiens

Ensembl Protein

ENSP00000377047

InnateDB Gene

IDBG-38364 (PTPRZ1)

Protein Structure

UniProt Annotation

Function

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein. Secreted {ECO:0000250}. Note=A secreted form is apparently generated by shedding of the extracellular domain. {ECO:0000250}.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain. {ECO:0000269PubMed:9653645}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006470	protein dephosphorylation
GO:0007409	axonogenesis
GO:0007417	central nervous system development
GO:0007611	learning or memory
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0048709	oligodendrocyte differentiation
GO:0070445	regulation of oligodendrocyte progenitor proliferation

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005887	integral component of plasma membrane
GO:0072534	perineuronal net

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001148 Alpha carbonic anhydrase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003961 Fibronectin, type III
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00194
PF00041
PF01108

PRINTS

PR00700

PIRSF

SMART

SM00194
SM01057
SM00404
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt