Version 5.4
Homo sapiens Protein: SLC39A2
Summary
InnateDB Protein IDBP-2440.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC39A2
Protein Name solute carrier family 39 (zinc transporter), member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000298681
InnateDB Gene IDBG-2438 (SLC39A2)
Protein Structure
UniProt Annotation
Function Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed only in prostate and uterine epithelial cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005385 zinc ion transmembrane transporter activity
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006829 zinc ion transport
GO:0030001 metal ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Protein Structure and Domains
PDB ID
InterPro IPR003689 Zinc/iron permease
PFAM PF02535
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NP94
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 29986
UniGene Hs.175783
RefSeq NP_055394
HUGO HGNC:17127
OMIM 612166
CCDS CCDS9563
HPRD 15385
IMGT
EMBL AF186081 AK314974 AL161668 AL355922 AY029483 BC096723 BC098254 BC110057 D83039
GenPept AAF35832 AAH96723 AAH98254 AAI10058 AAK40258 BAA94313 BAG37473

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca