Version 5.4
Homo sapiens Protein: PRIMA1
Summary
InnateDB Protein IDBP-244221.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRIMA1
Protein Name proline rich membrane anchor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000376848
InnateDB Gene IDBG-17669 (PRIMA1)
Protein Structure
UniProt Annotation
Function Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=In the brain, PRIMA linked to ACHE is found in membrane rafts. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0019899 enzyme binding
GO:0043495 protein anchor
Biological Process
GO:0042135 neurotransmitter catabolic process
GO:0051649 establishment of localization in cell
Cellular Component
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0031226 intrinsic component of plasma membrane
GO:0045202 synapse
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86XR5
PhosphoSite PhosphoSite-Q86XR5
TrEMBL A0A024R6J9
UniProt Splice Variant
Entrez Gene 145270
UniGene Hs.432401
RefSeq NP_821092
HUGO HGNC:18319
OMIM 613851
CCDS CCDS9912
HPRD 17907
IMGT
EMBL AY225516 AY225517 CH471061
GenPept AAO74853 AAO74854 EAW81532 EAW81534

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca