InnateDB Protein
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IDBP-244351.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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VTI1A
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Protein Name
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vesicle transport through interaction with t-SNAREs homolog 1A (yeast)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000376792
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InnateDB Gene
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IDBG-89850 (VTI1A)
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Protein Structure
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Function |
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. {ECO:0000269PubMed:18195106, ECO:0000269PubMed:19138172}.
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Subcellular Localization |
Cytoplasmic vesicle {ECO:0000269PubMed:19138172}. Golgi apparatus membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000727
Target SNARE coiled-coil domain
IPR007705
Vesicle transport v-SNARE, N-terminal
IPR010989
t-SNARE
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PFAM |
PF05739
PF05008
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PRINTS |
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PIRSF |
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SMART |
SM00397
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TIGRFAMs |
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Modification |
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SwissProt |
Q96AJ9
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PhosphoSite |
PhosphoSite-Q96AJ9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
143187
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UniGene |
Hs.596947
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RefSeq |
NP_660207
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HUGO |
HGNC:17792
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OMIM |
614316
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CCDS |
CCDS7575
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HPRD |
18290
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IMGT |
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EMBL |
AC022018
AK303646
AL139120
AL158212
BC017052
CH471066
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GenPept |
AAH17052
BAG64649
CAH71781
CAM15142
CAM22437
EAW49524
EAW49525
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