InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POU2AF1

Summary

InnateDB Protein

IDBP-244379.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POU2AF1

Protein Name

POU class 2 associating factor 1

Synonyms

BOB1; OBF-1; OBF1; OCAB;

Species

Homo sapiens

Ensembl Protein

ENSP00000376786

InnateDB Gene

IDBG-70789 (POU2AF1)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.

Subcellular Localization

Nucleus.

Disease Associations

Note=A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.

Tissue Specificity

B-cell specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding