InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DLAT

Summary

InnateDB Protein

IDBP-244409.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLAT

Protein Name

dihydrolipoamide S-acetyltransferase

Synonyms

DLTA; PDC-E2; PDCE2;

Species

Homo sapiens

Ensembl Protein

ENSP00000376771

InnateDB Gene

IDBG-71181 (DLAT)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0006090	pyruvate metabolic process
GO:0008152	metabolic process

Cellular Component

GO:0005759	mitochondrial matrix
GO:0045254	pyruvate dehydrogenase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000089 Biotin/lipoyl attachment
IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR004167 E3 binding
IPR006257 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
IPR011053 Single hybrid motif

PFAM

PF00364
PF00198
PF02817

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-