Version 5.4
Homo sapiens Protein: IKBIP
Summary
InnateDB Protein IDBP-244441.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IKBIP
Protein Name IKBKB interacting protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000376762
InnateDB Gene IDBG-52353 (IKBIP)
Protein Structure
UniProt Annotation
Function Target of p53/TP53 with pro-apoptotic function. {ECO:0000269PubMed:15389287}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:15389287}; Single-pass membrane protein {ECO:0000269PubMed:15389287}. Note=Isoform 4 deletion of the hydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell, suggesting that this region is responsible for endoplasmic reticulum localization.
Disease Associations
Tissue Specificity Expressed in vein endothelial cells. Isoform 4 is expressed in lung, kidney, spleen, thymus and skeletal muscle. {ECO:0000269PubMed:15389287}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0010165 response to X-ray
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q70UQ0
PhosphoSite PhosphoSite-Q70UQ0
TrEMBL
UniProt Splice Variant
Entrez Gene 121457
UniGene Hs.619381
RefSeq NP_963907
HUGO HGNC:26430
OMIM 609861
CCDS CCDS41822
HPRD 08092
IMGT
EMBL AJ539425 AJ539426 AJ539427 AK055613 AK123069 BC029415 BC051372 BC058933 CH471054
GenPept AAH29415 AAH51372 AAH58933 BAB70970 BAC85528 CAD62380 CAD62381 CAD62382 CAD62383 EAW97601

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca