InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTRH2

Summary

InnateDB Protein

IDBP-244443.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTRH2

Protein Name

peptidyl-tRNA hydrolase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376758

InnateDB Gene

IDBG-61806 (PTRH2)

Protein Structure

UniProt Annotation

Function

The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis. {ECO:0000250}.Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1. {ECO:0000269PubMed:15006356}.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004045	aminoacyl-tRNA hydrolase activity
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0008152	metabolic process
GO:0010629	negative regulation of gene expression
GO:2000210	positive regulation of anoikis
GO:2000811	negative regulation of anoikis