InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RPS6KB1

Summary

InnateDB Protein

IDBP-244455.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS6KB1

Protein Name

ribosomal protein S6 kinase, 70kDa, polypeptide 1

Synonyms

p70 S6KA; p70-alpha; p70-S6K; p70(S6K)-alpha; PS6K; S6K; S6K-beta-1; S6K1; STK14A;

Species

Homo sapiens

Ensembl Protein

ENSP00000376744

InnateDB Gene

IDBG-61938 (RPS6KB1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	83 [view]
Protein-Protein	79 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0008286	insulin receptor signaling pathway
GO:0031929	TOR signaling
GO:0043066	negative regulation of apoptotic process
GO:0045727	positive regulation of translation
GO:0045931	positive regulation of mitotic cell cycle
GO:0045948	positive regulation of translational initiation
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0030054	cell junction
GO:0043005	neuron projection
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016238 Ribosomal protein S6 kinase
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00433

PRINTS

PR00109

PIRSF

PIRSF000605

SMART

SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References