InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC17A8

Summary

InnateDB Protein

IDBP-244534.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC17A8

Protein Name

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376715

InnateDB Gene

IDBG-52855 (SLC17A8)

Protein Structure

UniProt Annotation

Function

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO:0000269PubMed:12151341}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250}.

Disease Associations

Deafness, autosomal dominant, 25 (DFNA25) [MIM:605583]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA25 expression is variable in terms of onset and rate of progression, with an age-dependent penetrance resembling an early-onset presbycusis, or senile deafness, a progressive bilateral loss of hearing that occurs in the aged. {ECO:0000269PubMed:18674745}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus. {ECO:0000269PubMed:12151341}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015293	symporter activity

Biological Process

GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0006836	neurotransmitter transport
GO:0007605	sensory perception of sound
GO:0055085	transmembrane transport

Cellular Component

GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

InterPro

IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8NDX2

PhosphoSite