InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STK38L

Summary

InnateDB Protein

IDBP-24459.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STK38L

Protein Name

serine/threonine kinase 38 like

Synonyms

NDR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000373684

InnateDB Gene

IDBG-24457 (STK38L)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of structural processes in differentiating and mature neuronal cells. {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Note=Associated with the actin cytoskeleton. Co- localizes with STK24/MST3 in the membrane.

Disease Associations

Tissue Specificity

Ubiquitously expressed with highest levels observed in the thymus. {ECO:0000269PubMed:15067004}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003779	actin binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0035556	intracellular signal transduction
GO:0051128	regulation of cellular component organization

Cellular Component

GO:0005737	cytoplasm
GO:0015629	actin cytoskeleton
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00433

PRINTS

PR00109

PIRSF

SMART

SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt