Version 5.4
Homo sapiens Protein: IDH3A
Summary
InnateDB Protein IDBP-24464.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IDH3A
Protein Name isocitrate dehydrogenase 3 (NAD+) alpha
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000299518
InnateDB Gene IDBG-24462 (IDH3A)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Mitochondrion.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004449 isocitrate dehydrogenase (NAD+) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR004434 Isocitrate dehydrogenase NAD-dependent
IPR024084 Isopropylmalate dehydrogenase-like domain
PFAM PF00180
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P50213
PhosphoSite PhosphoSite-P50213
TrEMBL H0YM64
UniProt Splice Variant
Entrez Gene 3419
UniGene Hs.659780
RefSeq NP_005521
HUGO HGNC:5384
OMIM 601149
CCDS CCDS10297
HPRD 03094
IMGT
EMBL AC090260 AK296002 AK315963 AK316051 AL442090 BC021967 CH471136 U07681
GenPept AAA85639 AAH21967 BAG58776 BAH14334 BAH14422 CAC09449 EAW99181 EAW99182

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca