InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EVL

Summary

InnateDB Protein

IDBP-244645.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EVL

Protein Name

Enah/Vasp-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376652

InnateDB Gene

IDBG-19953 (EVL)

Protein Structure

UniProt Annotation

Function

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Targeted to the leading edge of lamellipodia and the dital tip of stress fibers through interaction with a number of proteins. In activated T- cells, localizes to the F-actin collar and the distal tip of microspikes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	22 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005522	profilin binding
GO:0017124	SH3 domain binding

Biological Process

GO:0007015	actin filament organization
GO:0007166	cell surface receptor signaling pathway
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0008154	actin polymerization or depolymerization
GO:0009887	organ morphogenesis
GO:0010633	negative regulation of epithelial cell migration
GO:0030838	positive regulation of actin filament polymerization
GO:0051289	protein homotetramerization
GO:0051496	positive regulation of stress fiber assembly
GO:1900028	negative regulation of ruffle assembly