Version 5.4
Homo sapiens Protein: NEURL4
Summary
InnateDB Protein IDBP-24473.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEURL4
Protein Name neuralized homolog 4 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000319826
InnateDB Gene IDBG-230530 (NEURL4)
Protein Structure
UniProt Annotation
Function Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers. {ECO:0000269PubMed:22261722, ECO:0000269PubMed:22441691}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:22261722, ECO:0000269PubMed:22441691}. Note=Localizes to procentriole and daughter centriole in growing and quiescent cells (PubMed:22441691). May loose association with centrosomes during mitosis (PubMed:22261722). {ECO:0000269PubMed:22261722, ECO:0000269PubMed:22441691}.
Disease Associations
Tissue Specificity Widely expressed at high levels (including brain). {ECO:0000269PubMed:11347906}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005814 centriole
Protein Structure and Domains
PDB ID
InterPro IPR006573 NEUZ domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF07177
PRINTS
PIRSF
SMART SM00588
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96JN8
PhosphoSite PhosphoSite-Q96JN8
TrEMBL
UniProt Splice Variant
Entrez Gene 84461
UniGene Hs.654794
RefSeq NP_001005408
HUGO HGNC:34410
OMIM 615865
CCDS CCDS42252
HPRD 13894
IMGT
EMBL AB058690 AL136870 BC007227 BC073134
GenPept AAH07227 AAH73134 BAB47416 CAB66804

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca