InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PREX2

Summary

InnateDB Protein

IDBP-24488.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PREX2

Protein Name

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000288368

InnateDB Gene

IDBG-24486 (PREX2)

Protein Structure

UniProt Annotation

Function

Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase. {ECO:0000269PubMed:15304342, ECO:0000269PubMed:15304343, ECO:0000269PubMed:15897194}.

Subcellular Localization

Disease Associations

Tissue Specificity

Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart. {ECO:0000269PubMed:15304343}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0030675	Rac GTPase activator activity
GO:0030676	Rac guanyl-nucleotide exchange factor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0008344	adult locomotory behavior
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0048813	dendrite morphogenesis