Version 5.4
Homo sapiens Protein: PLEKHA1
Summary
InnateDB Protein IDBP-244921.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEKHA1
Protein Name pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000376547
InnateDB Gene IDBG-91879 (PLEKHA1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030165 PDZ domain binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
Biological Process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0031529 ruffle organization
GO:0045184 establishment of protein localization
GO:0050853 B cell receptor signaling pathway
GO:0051898 negative regulation of protein kinase B signaling
GO:0070301 cellular response to hydrogen peroxide
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0032587 ruffle membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HB21
PhosphoSite PhosphoSite-Q9HB21
TrEMBL R4GMZ9
UniProt Splice Variant
Entrez Gene 59338
UniGene Hs.715965
RefSeq
HUGO HGNC:14335
OMIM 607772
CCDS CCDS7629
HPRD 09686
IMGT
EMBL AF286160 AK057463 AK075159 BC001136 BC042458 BX664700 BX842242 CH471066
GenPept AAG15197 AAH01136 AAH42458 BAG51917 BAG52077 CAI23597 EAW49315 EAW49316 EAW49318 EAW49319

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca