InnateDB Protein
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IDBP-244964.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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B3GALNT1
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Protein Name
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beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
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Synonyms
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B3GALT3; beta3Gal-T3; galT3; Gb4Cer; GLCT3; GLOB; P; P1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000376532
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InnateDB Gene
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IDBG-63670 (B3GALNT1)
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Protein Structure
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Function |
Transfers N-acetylgalactosamine onto globotriaosylceramide. {ECO:0000269PubMed:10993897}.
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Subcellular Localization |
Golgi apparatus membrane; Single-pass type II membrane protein.
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Disease Associations |
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Tissue Specificity |
Higher expression in heart and brain, and to a lesser extent in lung, placenta, kidney and testis. Lower expression in liver, spleen and stomach. No expression in skeletal muscle. {ECO:0000269PubMed:10993897, ECO:0000269PubMed:9582303}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008378
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galactosyltransferase activity
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GO:0008499
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UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
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GO:0016757
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transferase activity, transferring glycosyl groups
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GO:0047273
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galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002659
Glycosyl transferase, family 31
IPR003378
Fringe-like
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PFAM |
PF01762
PF02434
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75752
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PhosphoSite |
PhosphoSite-O75752
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TrEMBL |
R4X604
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UniProt Splice Variant |
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Entrez Gene |
8706
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UniGene |
Hs.723510
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RefSeq |
NP_001033717
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HUGO |
HGNC:918
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OMIM |
603094
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CCDS |
CCDS3193
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HPRD |
09119
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IMGT |
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EMBL |
AB050855
AB050856
AB060691
AC021649
AF132731
AF154848
AF494103
AF494105
AF494106
AY359049
AY505345
AY505347
BC047618
CH471052
CR457170
DQ158095
FR871176
Y15062
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GenPept |
AAF66442
AAF72106
AAH47618
AAM96009
AAM96011
AAM96012
AAQ89408
AAS79229
AAS79231
AAZ67917
BAB17690
BAB17691
BAB91079
CAA75346
CAG33451
CCB78514
EAW78621
EAW78623
EAW78624
EAW78625
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