Version 5.4
Homo sapiens Protein: MVK
Summary
InnateDB Protein IDBP-245068.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MVK
Protein Name mevalonate kinase
Synonyms LRBP; MK; MVLK; POROK3;
Species Homo sapiens
Ensembl Protein ENSP00000376487
InnateDB Gene IDBG-56280 (MVK)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004496 mevalonate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR006204 GHMP kinase N-terminal domain
IPR006205 Mevalonate kinase
IPR006206 Mevalonate/galactokinase
IPR013750 GHMP kinase, C-terminal domain
IPR020568 Ribosomal protein S5 domain 2-type fold
PFAM PF00288
PF08544
PRINTS PR00959
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F5H8H2
UniProt Splice Variant
Entrez Gene 4598
UniGene Hs.130607
RefSeq NP_001288111
HUGO HGNC:7530
OMIM 251170
CCDS CCDS73522
HPRD 02015
IMGT
EMBL AC007570 AK293130 CH471054
GenPept BAH11458 EAW97870

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca