InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABCA5

Summary

InnateDB Protein

IDBP-245165.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCA5

Protein Name

ATP-binding cassette, sub-family A (ABC1), member 5

Synonyms

ABC13; EST90625;

Species

Homo sapiens

Ensembl Protein

ENSP00000376443

InnateDB Gene

IDBG-66446 (ABCA5)

Protein Structure

UniProt Annotation

Function

May play a role in the processing of autolysosomes. {ECO:0000250}.

Subcellular Localization

Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta. {ECO:0000269PubMed:12504089, ECO:0000269Ref.1}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0016887	ATPase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0033344	cholesterol efflux
GO:0034375	high-density lipoprotein particle remodeling
GO:0043691	reverse cholesterol transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0031902	late endosome membrane