Version 5.4
Homo sapiens Protein: TIRAP
Summary
InnateDB Protein IDBP-245167.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIRAP
Protein Name toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000376447
InnateDB Gene IDBG-75811 (TIRAP)
Protein Structure
UniProt Annotation
Function Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. {ECO:0000269PubMed:18292575, ECO:0000269PubMed:19509286}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:19948740}. Cell membrane {ECO:0000269PubMed:19948740}. Membrane {ECO:0000269PubMed:19948740}. Note=Colocalizes with DAB2IP at the plasma membrane.
Disease Associations
Tissue Specificity Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 80 [view]
Protein-Protein 74 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 6 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0030674 protein binding, bridging
GO:0035662 Toll-like receptor 4 binding
GO:0035663 Toll-like receptor 2 binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0030099 myeloid cell differentiation
GO:0030890 positive regulation of B cell proliferation
GO:0032496 response to lipopolysaccharide
GO:0032648 regulation of interferon-beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0032738 positive regulation of interleukin-15 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0035665 TIRAP-dependent toll-like receptor 4 signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044130 negative regulation of growth of symbiont in host
GO:0045087 innate immune response (InnateDB)
GO:0045088 regulation of innate immune response
GO:0045410 positive regulation of interleukin-6 biosynthetic process
GO:0046330 positive regulation of JNK cascade
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0071221 cellular response to bacterial lipopeptide
GO:0071223 cellular response to lipoteichoic acid
GO:0090023 positive regulation of neutrophil chemotaxis
GO:0090073 positive regulation of protein homodimerization activity
GO:2000340 positive regulation of chemokine (C-X-C motif) ligand 1 production
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030139 endocytic vesicle
GO:0032587 ruffle membrane
Protein Structure and Domains
PDB ID
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR017279 Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap
PFAM PF01582
PF13676
PRINTS
PIRSF PIRSF037750
SMART SM00255
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P58753
PhosphoSite PhosphoSite-P58753
TrEMBL A0A024R3M4
UniProt Splice Variant
Entrez Gene 114609
UniGene Hs.537126
RefSeq NP_001034750
HUGO HGNC:17192
OMIM 606252
CCDS CCDS8472
HPRD
IMGT
EMBL AB446477 AF378129 AF406652 AF410783 AK124298 AK313147 AP001318 AY282416 AY576785 AY576786 AY576787 BC032474 CH471065
GenPept AAH32474 AAL01160 AAL05036 AAL05627 AAP31973 AAT90417 AAT90418 AAT90419 BAG35965 BAG54027 BAG55254 EAW67687 EAW67688 EAW67689

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca