InnateDB Protein
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IDBP-245189.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ACTL6A
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Protein Name
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actin-like 6A
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Synonyms
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ACTL6; Arp4; ARPN-BETA; BAF53A; INO80K;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000376430
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InnateDB Gene
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IDBG-66303 (ACTL6A)
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Protein Structure
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Function |
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand- bound VDR-mediated transrepression of the CYP27B1 gene. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. {ECO:0000250, ECO:0000269PubMed:12837248, ECO:0000269PubMed:14966270}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:18026119}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
87
[view]
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Protein-Protein |
85
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0000980
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RNA polymerase II distal enhancer sequence-specific DNA binding
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GO:0003682
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chromatin binding
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GO:0003713
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transcription coactivator activity
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GO:0005515
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protein binding
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GO:0031492
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nucleosomal DNA binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004000
Actin-related protein
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PFAM |
PF00022
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PRINTS |
PR00190
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PIRSF |
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SMART |
SM00268
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TIGRFAMs |
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Modification |
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SwissProt |
O96019
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PhosphoSite |
PhosphoSite-O96019
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TrEMBL |
D3DNS0
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UniProt Splice Variant |
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Entrez Gene |
86
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UniGene |
Hs.435326
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RefSeq |
NP_829888
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HUGO |
HGNC:24124
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OMIM |
604958
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CCDS |
CCDS43174
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HPRD |
05389
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IMGT |
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EMBL |
AB015907
AB060168
AB061315
AC090425
AF041474
AK021756
AL136608
BC000949
BC001391
BC036371
CH471052
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GenPept |
AAC94991
AAH00949
AAH01391
AAH36371
BAA74577
BAB87844
BAB87848
BAG51043
CAB66543
EAW78397
EAW78398
EAW78399
EAW78400
EAW78401
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