InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ETS1

Summary

InnateDB Protein

IDBP-245191.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ETS1

Protein Name

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

Synonyms

ETS-1; EWSR2; p54;

Species

Homo sapiens

Ensembl Protein

ENSP00000376436

InnateDB Gene

IDBG-75897 (ETS1)

Protein Structure

UniProt Annotation

Function

Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. {ECO:0000269PubMed:10698492, ECO:0000269PubMed:11909962, ECO:0000269PubMed:15247905, ECO:0000269PubMed:15592518}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27.

Disease Associations

Tissue Specificity

Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney. {ECO:0000269PubMed:19377509, ECO:0000269PubMed:20378371}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	77 [view]
Protein-Protein	68 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0035035	histone acetyltransferase binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001666	response to hypoxia
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006955	immune response
GO:0007565	female pregnancy
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009611	response to wounding
GO:0009612	response to mechanical stimulus
GO:0010595	positive regulation of endothelial cell migration
GO:0010715	regulation of extracellular matrix disassembly
GO:0021854	hypothalamus development
GO:0021983	pituitary gland development
GO:0030335	positive regulation of cell migration
GO:0030578	PML body organization
GO:0032355	response to estradiol
GO:0034616	response to laminar fluid shear stress
GO:0042981	regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045765	regulation of angiogenesis
GO:0045766	positive regulation of angiogenesis
GO:0045786	negative regulation of cell cycle
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046677	response to antibiotic
GO:0048870	cell motility
GO:0051272	positive regulation of cellular component movement
GO:0060055	angiogenesis involved in wound healing
GO:0060206	estrous cycle phase
GO:0070301	cellular response to hydrogen peroxide
GO:0070555	response to interleukin-1