Version 5.4
Homo sapiens Protein: CD300LB
Summary
InnateDB Protein IDBP-245290.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD300LB
Protein Name CD300 molecule-like family member b
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000376397
InnateDB Gene IDBG-67310 (CD300LB)
Protein Structure
UniProt Annotation
Function Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. {ECO:0000269PubMed:16920917, ECO:0000269PubMed:17928527}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed exclusively in myeloid lineages. {ECO:0000269PubMed:16920917}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002446 neutrophil mediated immunity
GO:0033005 positive regulation of mast cell activation
GO:0045087 innate immune response
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A8K4G0
PhosphoSite PhosphoSite-NP_777552
TrEMBL
UniProt Splice Variant
Entrez Gene 124599
UniGene Hs.313343
RefSeq NP_777552
HUGO HGNC:30811
OMIM 610705
CCDS CCDS11700
HPRD 18223
IMGT
EMBL AC079325 AF427618 AK290925 AY359025 AY646929 BC028091 CH471099
GenPept AAH28091 AAN86133 AAQ89384 AAV69612 BAF83614 EAW89170

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca