InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WASF1

Summary

InnateDB Protein

IDBP-245356.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WASF1

Protein Name

WAS protein family, member 1

Synonyms

SCAR1; WAVE; WAVE1;

Species

Homo sapiens

Ensembl Protein

ENSP00000376367

InnateDB Gene

IDBG-95204 (WASF1)

Protein Structure

UniProt Annotation

Function

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell junction, synapse {ECO:0000250}. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas.

Disease Associations

Tissue Specificity

Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	51 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0006461	protein complex assembly
GO:0006928	cellular component movement
GO:0016601	Rac protein signal transduction
GO:0030036	actin cytoskeleton organization
GO:0030041	actin filament polymerization
GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation