Version 5.4
Homo sapiens Protein: RBM19
Summary
InnateDB Protein IDBP-245412.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBM19
Protein Name RNA binding motif protein 19
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000376344
InnateDB Gene IDBG-58877 (RBM19)
Protein Structure
UniProt Annotation
Function Plays a role in embryo pre-implantation development. {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:12429849, ECO:0000269PubMed:16027046}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Chromosome {ECO:0000250}. Note=In discrete foci distributed throughout the cytoplasm and nucleoplasm during the 4 to 8 cell stages and the morula stage, but not in the periphery of the nucleolar precursor body (NPB). During blastocyst development, becomes increasingly localized to the nucleolus and less to the cytoplasm. At the late blastocyst stage, localized predominantly in the nucleolus. Localized in the nucleolus during interphase and to the perichromosomal sheath during mitosis. Does not colocalize in the cytoplasm with GW182 in P-bodies. May translocate to the nucleolus upon early embryonic development (By similarity). Colocalizes with NPM1 during interphase. By late prophase, metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to NPB. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the crypts of Lieberkuhn of the intestine and in intestinal neoplasia (at protein level). {ECO:0000269PubMed:16027046}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007275 multicellular organismal development
GO:0040019 positive regulation of embryonic development
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR003954 RNA recognition motif domain, eukaryote
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
SM00361
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y4C8
PhosphoSite PhosphoSite-Q9Y4C8
TrEMBL
UniProt Splice Variant
Entrez Gene 9904
UniGene Hs.7482
RefSeq NP_001140170
HUGO HGNC:29098
OMIM
CCDS CCDS9172
HPRD 15225
IMGT
EMBL AB014582 AC009731 AC073863 AC090669 AK291444 AK314606 AL117547 BC004289 BC006137
GenPept AAH04289 AAH06137 BAA31657 BAF84133 BAG37176 CAB55987

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca