InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF24

Summary

InnateDB Protein

IDBP-2455.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF24

Protein Name

zinc finger protein 24

Synonyms

KOX17; RSG-A; Zfp191; ZNF191; ZSCAN3;

Species

Homo sapiens

Ensembl Protein

ENSP00000261332

InnateDB Gene

IDBG-2453 (ZNF24)

Protein Structure

UniProt Annotation

Function

Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro. {ECO:0000250, ECO:0000269PubMed:10585455}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00187, ECO:0000269PubMed:24224020}.

Disease Associations

Tissue Specificity

Expressed in many tissues except in heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	53 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0042552	myelination
GO:0045892	negative regulation of transcription, DNA-templated