Version 5.4
Homo sapiens Protein: CEP85L
Summary
InnateDB Protein IDBP-245532.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEP85L
Protein Name chromosome 6 open reading frame 204
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000376288
InnateDB Gene IDBG-95865 (CEP85L)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000305PubMed:21399614}. Note=Subcellular experiments using a GFP-tagged system produced a weak signal, rendering it difficult to confirm centrosome association.
Disease Associations Note=A chromosomal aberration involving CEP85L is found in a patient with T-lymphoblastic lymphoma (T-ALL) and an associated myeloproliferative neoplasm (MPN) with eosinophilia. Translocation t(5;6)(q33-34;q23) with PDGFRB. The translocation fuses the 5'-end of CEP85L (isoform 4) to the 3'-end of PDGFRB.
Tissue Specificity Isoform 1 and isoform 4 are expressed in spleen, lymph, thymus, tonsil and peripheral blood leukocytes, with isoform 1 expressed at higher levels. Isoform 4 is detected in K-562 leukemia cells and in the blood of precursor T lymphoblastic lymphoma (T-ALL) patients. {ECO:0000269PubMed:21938754}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5SZL2
PhosphoSite PhosphoSite-Q5SZL2
TrEMBL
UniProt Splice Variant
Entrez Gene 387119
UniGene Hs.733475
RefSeq
HUGO HGNC:21638
OMIM
CCDS
HPRD 12874
IMGT
EMBL AF308284 AL359634 AL390069 AL589993 AY313778 BC110835 BC126140 BC126142 CH471051 Z99496
GenPept AAG48252 AAI10836 AAI26141 AAI26143 AAP81009 CAI14134 CAI14135 CAI16048 CAI21605 CAI21606 CAM19611 CAM28257 CAM28259 EAW48196 EAW48197

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca