InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF34

Summary

InnateDB Protein

IDBP-245613.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF34

Protein Name

ring finger protein 34

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376258

InnateDB Gene

IDBG-61735 (RNF34)

Protein Structure

UniProt Annotation

Function

Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Protects cells against apoptosis induced by TNF. Binds phosphatidylinositol 5-phosphate and phosphatidylinositol 3- phosphate. {ECO:0000269PubMed:12118383, ECO:0000269PubMed:15069192, ECO:0000269PubMed:15897238}.

Subcellular Localization

Nucleus speckle. Endomembrane system; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes. {ECO:0000269PubMed:12118383, ECO:0000269PubMed:15069192}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:1901981	phosphatidylinositol phosphate binding

Biological Process

GO:0016567	protein ubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis