InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCTD11

Summary

InnateDB Protein

IDBP-24572.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCTD11

Protein Name

potassium channel tetramerisation domain containing 11

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000328352

InnateDB Gene

IDBG-237202 (KCTD11)

Protein Structure

UniProt Annotation

Function

Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. {ECO:0000269PubMed:15249678, ECO:0000269PubMed:20081843, ECO:0000269PubMed:21237243}.

Subcellular Localization

Disease Associations

Tissue Specificity

Higher expression in cerebellum than in whole brain and lower expression in medulloblastoma. {ECO:0000269PubMed:15249678}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007049	cell cycle
GO:0007399	nervous system development
GO:0007406	negative regulation of neuroblast proliferation
GO:0016567	protein ubiquitination
GO:0030154	cell differentiation
GO:0040008	regulation of growth
GO:0042127	regulation of cell proliferation
GO:0045666	positive regulation of neuron differentiation
GO:0045879	negative regulation of smoothened signaling pathway
GO:0051260	protein homooligomerization