Version 5.4
Homo sapiens Protein: PIGX
Summary
InnateDB Protein IDBP-245758.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIGX
Protein Name phosphatidylinositol glycan anchor biosynthesis, class X
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000376192
InnateDB Gene IDBG-71308 (PIGX)
Protein Structure
UniProt Annotation
Function Essential component of glycosylphosphatidylinositol- mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006501 C-terminal protein lipidation
GO:0006506 GPI anchor biosynthetic process
GO:0016254 preassembly of GPI anchor in ER membrane
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR013233 Glycosylphosphatidylinositol-mannosyltransferase I, PIG-X/PBN1
PFAM PF08320
PRINTS
PIRSF
SMART SM00780
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TBF5
PhosphoSite PhosphoSite-Q8TBF5
TrEMBL C9JLT7
UniProt Splice Variant
Entrez Gene 54965
UniGene Hs.608993
RefSeq NP_060331
HUGO HGNC:26046
OMIM 610276
CCDS CCDS3320
HPRD 07921
IMGT
EMBL AC055725 AK000529 BC022542 CH471191
GenPept AAH22542 BAA91233 EAW53638 EAW53640

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca