InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYO1B

Summary

InnateDB Protein

IDBP-245902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO1B

Protein Name

myosin IB

Synonyms

myr1;

Species

Homo sapiens

Ensembl Protein

ENSP00000376132

InnateDB Gene

IDBG-77658 (MYO1B)

Protein Structure

UniProt Annotation

Function

Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0051015	actin filament binding

Biological Process

GO:0006892	post-Golgi vesicle-mediated transport
GO:0007015	actin filament organization
GO:0008152	metabolic process
GO:0030048	actin filament-based movement
GO:0051017	actin filament bundle assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005903	brush border
GO:0010008	endosome membrane
GO:0016459	myosin complex
GO:0030175	filopodium
GO:0032588	trans-Golgi network membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR010926 Myosin tail 2
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF06017

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt