InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZBTB32

Summary

InnateDB Protein

IDBP-246146.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZBTB32

Protein Name

zinc finger and BTB domain containing 32

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376035

InnateDB Gene

IDBG-44976 (ZBTB32)

Protein Structure

UniProt Annotation

Function

DNA-binding protein that binds to the to a 5'- TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10572087}. Note=Located in nuclear speckles.

Disease Associations

Tissue Specificity

Predominantly expressed in testis. Some isoforms are ubiquitously expressed. {ECO:0000269PubMed:10544010}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001817	regulation of cytokine production
GO:0006281	DNA repair
GO:0006366	transcription from RNA polymerase II promoter
GO:0030097	hemopoiesis
GO:0042098	T cell proliferation
GO:2001141	regulation of RNA biosynthetic process