InnateDB Protein
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IDBP-246155.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MAP2
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Protein Name
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microtubule-associated protein 2
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Synonyms
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MAP2A; MAP2B; MAP2C;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000376032
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InnateDB Gene
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IDBG-79788 (MAP2)
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Protein Structure
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Function |
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N- terminal Met-Val and Met-Thr sequences in vivo.Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
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Subcellular Localization |
Cytoplasm {ECO:0000255HAMAP-Rule:MF_03175, ECO:0000269PubMed:21537465}. Note=About 30% of expressed METAP2 associates with polysomes.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
48
[view]
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Protein-Protein |
47
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001084
Microtubule associated protein, tubulin-binding repeat
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PFAM |
PF00418
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P11137
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PhosphoSite |
PhosphoSite-P11137
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TrEMBL |
Q59FX9
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UniProt Splice Variant |
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Entrez Gene |
4133
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UniGene |
Hs.736133
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RefSeq |
NP_114033
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HUGO |
HGNC:6839
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OMIM |
157130
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CCDS |
CCDS2385
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HPRD |
01140
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IMGT |
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EMBL |
AB209330
AC006385
AC019106
AC079833
AC108072
BC038857
BC110423
BC117123
BC143245
CH471063
M25668
U01828
U89329
U89330
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GenPept |
AAA03354
AAA59552
AAB48097
AAB48098
AAH38857
AAI10424
AAI17124
AAI43246
BAD92567
EAW70459
EAW70460
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