Version 5.4
Homo sapiens Protein: NDUFS2
Summary
InnateDB Protein IDBP-246185.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDUFS2
Protein Name NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
Synonyms CI-49;
Species Homo sapiens
Ensembl Protein ENSP00000376018
InnateDB Gene IDBG-104226 (NDUFS2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003954 NADH dehydrogenase activity
GO:0005515 protein binding
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0009055 electron carrier activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0046872 metal ion binding
GO:0048038 quinone binding
GO:0051287 NAD binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0006979 response to oxidative stress
GO:0022904 respiratory electron transport chain
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005747 mitochondrial respiratory chain complex I
Protein Structure and Domains
PDB ID
InterPro IPR001135 NADH-quinone oxidoreductase, subunit D
IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H
IPR029014 NiFe hydrogenase-like
PFAM PF00346
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75306
PhosphoSite PhosphoSite-O75306
TrEMBL Q9HC12
UniProt Splice Variant
Entrez Gene 4720
UniGene Hs.173611
RefSeq NP_001159631
HUGO HGNC:7708
OMIM 602985
CCDS CCDS53404
HPRD 04285
IMGT
EMBL AF013160 AF050640 AF183172 AF183173 AK301641 AK314807 AK315977 AL590714 BC000170 BC001456 BC008868 CH471121
GenPept AAC27453 AAC34362 AAG13808 AAG13809 AAH00170 AAH01456 AAH08868 BAH13528 BAH14348 CAH72148 EAW52625 EAW52626

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca