InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EZR

Summary

InnateDB Protein

IDBP-246189.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EZR

Protein Name

ezrin

Synonyms

CVIL; CVL; HEL-S-105; VIL2;

Species

Homo sapiens

Ensembl Protein

ENSP00000376016

InnateDB Gene

IDBG-98477 (EZR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 138 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	138 [view]
Protein-Protein	135 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0008092	cytoskeletal protein binding

Biological Process

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0019898	extrinsic component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR000798 Ezrin/radixin/moesin like
IPR008954 Moesin tail domain
IPR011174 Ezrin/radixin/moesin
IPR011259 Ezrin/radixin/moesin, C-terminal
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029071 Ubiquitin-related domain

PFAM

PF00769
PF09379
PF09380
PF00373

PRINTS

PR00661
PR00935

PIRSF

PIRSF002305

SMART

SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References