InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEMA3D

Summary

InnateDB Protein

IDBP-24629.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEMA3D

Protein Name

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000284136

InnateDB Gene

IDBG-24627 (SEMA3D)

Protein Structure

UniProt Annotation

Function

Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0030154	cell differentiation

Cellular Component

GO:0005576	extracellular region
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001627 Sema domain
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR016201 Plexin-like fold

PFAM

PF01403
PF07686

PRINTS

PIRSF

SMART

SM00630
SM00409
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95025