InnateDB Protein
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IDBP-246304.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MPZL1
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Protein Name
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myelin protein zero-like 1
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Synonyms
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MPZL1b; PZR; PZR1b; PZRa; PZRb;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000375968
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InnateDB Gene
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IDBG-104564 (MPZL1)
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Protein Structure
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Function |
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. {ECO:0000269PubMed:11751924, ECO:0000269PubMed:12410637}.
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line. {ECO:0000269PubMed:12410637, ECO:0000269PubMed:12684038, ECO:0000269PubMed:9792637}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0007169
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transmembrane receptor protein tyrosine kinase signaling pathway
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GO:0007267
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cell-cell signaling
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O95297
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PhosphoSite |
PhosphoSite-O95297
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9019
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UniGene |
Hs.705572
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RefSeq |
NP_001139663
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HUGO |
HGNC:7226
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OMIM |
604376
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CCDS |
CCDS53425
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HPRD |
05086
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IMGT |
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EMBL |
AF087020
AF092424
AF092425
AF095726
AF095727
AF239756
AF478447
AF478448
AK297112
AL356532
AY359019
BC007881
CH471067
CR542160
Z99943
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GenPept |
AAC72231
AAD55346
AAD55347
AAF00083
AAF00084
AAF63499
AAH07881
AAO14645
AAO14646
AAO14647
AAQ89378
BAH12501
CAC36033
CAG46957
CAI20143
CAI20144
CAQ52583
CAQ52584
CAQ52610
CAQ52611
EAW90800
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