InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MLLT4

Summary

InnateDB Protein

IDBP-246321.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLLT4

Protein Name

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4

Synonyms

AF6;

Species

Homo sapiens

Ensembl Protein

ENSP00000375956

InnateDB Gene

IDBG-99115 (MLLT4)

Protein Structure

UniProt Annotation

Function

Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.

Subcellular Localization

Cell junction, adherens junction. Note=Not found at cell-matrix AJs.

Disease Associations

Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with KMT2A/MLL1. The result is a rogue activator protein.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	81 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding

Biological Process

GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0045216	cell-cell junction organization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0030054	cell junction

Protein Structure and Domains

PDB ID

InterPro

IPR000159 Ras-association
IPR000253 Forkhead-associated (FHA) domain
IPR001478 PDZ domain
IPR002710 Dilute
IPR008984 SMAD/FHA domain
IPR018444 Dil domain
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00498
PF00595
PF13180
PF01843

PRINTS

PIRSF

SMART

SM00314
SM00240
SM00228

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P55196