Version 5.4
Homo sapiens Protein: TTLL4
Summary
InnateDB Protein IDBP-246342.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTLL4
Protein Name tubulin tyrosine ligase-like family, member 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000375951
InnateDB Gene IDBG-81139 (TTLL4)
Protein Structure
UniProt Annotation
Function Polyglutamylase which preferentially modifies beta- tubulin and nucleosome assembly proteins NAP1 and NAP2. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). {ECO:0000250}.
Subcellular Localization Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Note=Located in cilia. In some cells, also found in basal bodies (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015631 tubulin binding
GO:0016874 ligase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0018095 protein polyglutamylation
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005929 cilium
Protein Structure and Domains
PDB ID
InterPro IPR004344 Tubulin-tyrosine ligase/Tubulin polyglutamylase
PFAM PF03133
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14679
PhosphoSite PhosphoSite-Q14679
TrEMBL C9JB60
UniProt Splice Variant
Entrez Gene 9654
UniGene Hs.740133
RefSeq NP_055455
HUGO HGNC:28976
OMIM
CCDS CCDS2422
HPRD 15586
IMGT
EMBL AC009974 AK291770 BC021707 CH471063 D79995
GenPept AAH21707 BAA11490 BAF84459 EAW70651 EAW70652

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca