Homo sapiens Protein: PAX3
Summary
InnateDB Protein IDBP-246410.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAX3
Protein Name paired box 3
Synonyms CDHS; HUP2; WS1; WS3;
Species Homo sapiens
Ensembl Protein ENSP00000375921
InnateDB Gene IDBG-82144 (PAX3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 24 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0071837 HMG box domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001755 neural crest cell migration
GO:0001843 neural tube closure
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007605 sensory perception of sound
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0014807 regulation of somitogenesis
GO:0016477 cell migration
GO:0021527 spinal cord association neuron differentiation
GO:0021915 neural tube development
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048066 developmental pigmentation
GO:0048663 neuron fate commitment
GO:0060594 mammary gland specification
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001356 Homeobox domain
IPR001523 Paired domain
IPR009057 Homeodomain-like
IPR022106 Paired box protein 7
PFAM PF00046
PF00292
PF12360
PRINTS PR00027
PIRSF
SMART SM00389
SM00351
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P23760
PhosphoSite PhosphoSite-P23760
TrEMBL
UniProt Splice Variant
Entrez Gene 5077
UniGene Hs.42146
RefSeq NP_852124
HUGO HGNC:8617
OMIM 606597
CCDS CCDS2448
HPRD 09421
IMGT
EMBL AC010980 AC012591 AK291278 AY251279 AY251280 AY633656 BC063547 BC101299 BC101300 BC101301 BC101302 BC114363 CH471063 L10614 S69369 S69370 S83614 U12258 U12259 U12260 U12262 U12263 X15043 X15252 X15253 Z29972 Z29973 Z29974
GenPept AAA80573 AAA80574 AAA91849 AAB21476 AAB30167 AAB30168 AAH63547 AAI01300 AAI01301 AAI01302 AAI01303 AAI14364 AAP13872 AAP13873 AAT47737 AAY14900 BAF83967 CAA33145 EAW70789 EAW70791 EAW70794 EAW70796