InnateDB Protein
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IDBP-246436.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SPHKAP
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Protein Name
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SPHK1 interactor, AKAP domain containing
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000375909
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InnateDB Gene
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IDBG-82700 (SPHKAP)
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Protein Structure
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Function |
Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1. {ECO:0000269PubMed:12080051, ECO:0000269PubMed:20394097}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:12080051, ECO:0000269PubMed:20394097}. Note=Colocalizes with SPHK1 in the cytoplasm.
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Disease Associations |
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Tissue Specificity |
Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in spleen, ovary and brain. {ECO:0000269PubMed:12080051, ECO:0000269PubMed:20394097}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR018292
A-kinase anchor 110kDa, C-terminal
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PFAM |
PF05716
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q2M3C7
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PhosphoSite |
PhosphoSite-Q2M3C7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
80309
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UniGene |
Hs.609616
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RefSeq |
NP_001136116
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HUGO |
HGNC:30619
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OMIM |
611646
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CCDS |
CCDS46537
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HPRD |
18052
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IMGT |
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EMBL |
AB051465
BC104954
BC104956
CR749297
CR749494
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GenPept |
AAI04955
AAI04957
BAB21769
CAH18152
CAH18317
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