Version 5.4
Homo sapiens Protein: LGALS16
Summary
InnateDB Protein IDBP-246446.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS16
Protein Name lectin, galactoside-binding, soluble, 16
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000375904
InnateDB Gene IDBG-405006 (LGALS16)
Protein Structure
UniProt Annotation
Function Binds lactose with high affinity. Strong inducer of T- cell apoptosis. {ECO:0000269PubMed:19497882}.
Subcellular Localization
Disease Associations
Tissue Specificity Predominantly and highly expressed in the placenta where it is localized mainly in the syncytiotrophoblast and in the endothelia of fetal vessels. Also detected in the amnion and chorionic trophoblasts in fetal membranes. {ECO:0000269PubMed:19497882}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
GO:0030395 lactose binding
Biological Process
GO:0006915 apoptotic process
GO:0070234 positive regulation of T cell apoptotic process
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID
InterPro IPR001079 Galectin, carbohydrate recognition domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF00337
PRINTS
PIRSF
SMART SM00276
SM00908
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A8MUM7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 148003
UniGene Hs.667238
RefSeq NP_001177370
HUGO HGNC:40039
OMIM
CCDS CCDS54267
HPRD
IMGT
EMBL AC005515 AC093051 FJ613352
GenPept ACR09652

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca