InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALPP

Summary

InnateDB Protein

IDBP-246493.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALPP

Protein Name

alkaline phosphatase, placental

Synonyms

ALP; PALP; PLAP; PLAP-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000375881

InnateDB Gene

IDBG-83209 (ALPP)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cell membrane; Lipid-anchor, GPI-anchor.

Disease Associations

Tissue Specificity

Detected in placenta (at protein level). {ECO:0000269PubMed:20693656}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004035	alkaline phosphatase activity
GO:0008270	zinc ion binding
GO:0016791	phosphatase activity

Biological Process

GO:0008152	metabolic process
GO:0016311	dephosphorylation

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0031225	anchored component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001952 Alkaline phosphatase
IPR017850 Alkaline-phosphatase-like, core domain

PFAM

PF00245

PRINTS

PR00113

PIRSF

SMART

SM00098

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P05187

PhosphoSite

PhosphoSite-P05187

TrEMBL

UniProt Splice Variant

Entrez Gene

250

UniGene

Hs.284255

RefSeq

NP_001623

HUGO

HGNC:439

OMIM

171800

CCDS

CCDS2490

HPRD

IMGT

EMBL

AC068134 BC009647 BC068501 BC094743 M12551 M13077 M14169 M14170 M19159

GenPept

AAA51706 AAA51708 AAA51709 AAA51710 AAC97139 AAH09647 AAH68501 AAH94743 AAY24087